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Science & Clinical Studies
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Pilot evaluation of flaxseed for the management of hot flashes.
View Article on Pub Med Web site
Pruthi S, Thompson SL, Novotny PJ, Barton DL, Kottschade LA, Tan AD, Sloan JA, Loprinzi CL.
Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA. pruthi.sandhya@mayo.edu
The objective of this study was to evaluate, in a phase 2 pilot study, tolerability and the effect of 6 weeks of flaxseed therapy on hot flash scores in women not wishing to receive estrogen therapy. Eligibility included 14 hot flashes per week for at least 1 month. In the baseline week, participants took no study medication and documented the characteristics of their hot flashes. Thereafter, crushed flaxseed was administered at 40 g daily. Participants provided weekly toxicity reports and health-related quality of life information. The primary end point was a change in hot flash score prospectively reported in a daily hot flash diary. Thirty women were enrolled between June 17 and November 8, 2005. The mean decrease in hot flash scores after flaxseed therapy was 57% (median decrease 62%). The mean reduction in daily hot flash frequency was 50% (median reduction 50%), from 7.3 hot flashes to 3.6. Fourteen of the 28 participants (50%) experienced mild or moderate abdominal distention. Eight participants (29%) experienced mild diarrhea, one experienced flatulence, and six (21%) withdrew because of toxicities. This study suggests that dietary therapy decreases hot flash activity in women not taking estrogen therapy. This reduction is greater than what would be expected with placebo.
PMID: 17761129 [PubMed - indexed for MEDLINE]
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Anticancer
effects of a plant lignan 7-hydroxymatairesinol on a prostate
cancer model in vivo.
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View Article on Pub Med Web site
Bylund A, Saarinen N, Zhang
JX, Bergh A, Widmark A, Johansson A, Lundin E, Adlercreutz
H, Hallmans G, Stattin P, Makela S.
University of Turku, Functional
Foods Forum, FI-20014 Turku, Finland.
Clinical intervention
studies and experimental studies with lignan-rich diets suggest
that lignans may have inhibitory effects on prostate cancer,
but no clinical or experimental studies with purified lignans
have been published. The purpose of this study was to investigate
the effect of a plant lignan 7-hydroxymatairesinol (HMR)
on LNCaP human prostate cancer xenografts in athymic mice .
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Antioxidant and antitumor effects
of hydroxymatairesinol
(HM-3000, HMR), a lignan isolated from the
knots of spruce.
Download Article in PDF Format 92k
View Article on Pub Med Web site
Kangas L, Saarinen N, Mutanen M, Ahotupa M, Hirsinummi
R, Unkila M, Perala M, Soininen P, Laatikainen R, Korte H, Santti
R.
Hormos Nutraceutical Ltd, Turku, Finland.
The antioxidant properties
of hydroxymatairesinol (HM-3000) were studied in vitro in lipid
peroxidation, superoxide and peroxyl radical scavenging, and
LDL-oxidation models in comparison with the known synthetic antioxidants
Trolox (a water-soluble vitamin E derivative), butylated hydroxyanisol
(BHA) and butylated hydroxytoluene (BHT). On a molar basis
HM-3000 was a more effective antioxidant than Trolox in all assays
and more effective than BHT or BHA in . . .
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Association
between low serum enterolactone and increased plasma F2-isoprostanes,
a measure of lipid peroxidation.
Download Article in PDF Format 88k
View Article on Pub Med Web site
Vanharanta
M, Voutilainen S, Nurmi T, Kaikkonen J, Roberts LJ, Morrow JD, Adlercreutz
H, Salonen JT.
Research Institute of Public Health, University of
Kuopio, PO Box 1627, 70211 Kuopio, Finland.
Evidence suggests that
low serum enterolactone concentration might be an independent
risk factor for acute coronary events. Enterolactone is a lignan,
which is formed by intestinal bacteria from precursors in plant
foods. Due to the biphenolic structure of enterolactone, it
could act as an antioxidant and through this contribute to cardiovascular
health. The aim of this study was to test the hypothesis .
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Chemopreventative activity of crude
hydroxymatairesinol (HMR) extract in Apc(Min) mice [corrected].
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View Article on Pub Med Web site
Oikannen
SI, Pajari AM, Mutanen M.
Department of Applied Chemistry and
Microbiology (Nutrition), University of Helsinki, P.O. Box 27,
FIN-00014, Helsinki, Finland.
We studied the effects of a lignan,
hydroxymatairesinol (HMR), and rye bran on intestinal tumor development
in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min)
mice. HMR showed a strong chemopreventive effect in this animal
model. The mean number of adenomas in the small intestine was
significantly lower (26.6+/-11.0, P<0.05) in mice
fed the TNS tumor promoter insulin and HMR when compared with
the insulin and insulin/rye bran fed mice (39.6+/-8.9 and 36.0+/-7.4,
respectively). HMR resulted in normalization of beta-catenin levels.
. .
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Chemopreventive effects of hydroxymatairesinol
on uterine
carcinogenesis in Donryu rats.
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View Article on Pub Med Web site
Katsuda S, Yoshida M, Saarinen
N, Smeds A, Nakae D, Santti R, Maekawa A.
Department of Biological
Safety Research, Japan Food Research Laboratories, Tama-shi,
Tokyo 206-0025, Japan. katudas@jfrl.or.jp
Hydroxymatairesinol
(HMR), obtained from the heartwood of spruce (Picea abies), has
been demonstrated to exert chemo-preventive effects on the development
of mammary tumors in rats. To examine the influence of HMR on
uterine carcinogenesis, adult Donryu rats were initiated with a
single intrauterine treatment of N-ethyl-N'-nitro-N-nitrosoguanidine
(ENNG) at 11 weeks of age and fed thereafter 0, 200, or 600 ppm
HMR mixed in the soy-containing diet until . . .
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Dietary intake of phytoestrogens is associated with
a favorable metabolic cardiovascular risk profile in postmenopausal
U.S.women: the Framingham study.
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View Article on Pub Med Web site
de Kleijn MJ, van der Schouw YT,
Wilson PW, Grobbee DE, Jacques PF.
Julius Center for General Practice
and Patient Oriented Research, University Medical Center, Utrecht,
The Netherlands.
Hypertension, central obesity
and dyslipidemia are associated with high cardiovascular risk.
Estrogen therapy in women has beneficial effects on some of these
metabolic cardiovascular risk factors. It is not known whether
dietary estrogens have similar effects, especially in Western
populations. We studied the association between dietary phytoestrogen
intake and metabolic cardiovascular risk . . .
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Enterolactone
in breast cyst fluid: correlation with EGF and breast cancer
risk.
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View Article on Pub Med Web site
Boccardo F, Lunardi GL, Petti AR, Rubagotti
A.
Professorial Unit of Medical Oncology, University and National
Cancer Research Institute, Genoa, Italy. francesco.boccardo@istge.it
The
purpose of our study was to investigate whether enterolactone
does accumulate into breast cyst fluid and whether it correlates
with breast cancer risk. We included 258 women who had at least
one cyst aspiration and known intracystic cation and epidermal
growth factor (EGF) concentration values. For 191 of such women
serum aliquots were also available. The median value of serum . .
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Risk of cardiovascular disease-related
and all-cause death according to serum concentrations of enterolactone:
Kuopio Ischaemic Heart Disease Risk Factor Study.
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View Article on Pub Med Web site
Vanharanta M, Voutilainen
S, Rissanen TH, Adlercreutz H, Salonen JT.Research Institute
of Public Health, University of Kuopio, Harjulantie 1B, 70210 Kuopio,
Finland.
BACKGROUND: Enterolactone is a plant-derived compound that
has been associated with a reduced risk of acute coronary events
and cancer. Several studies have suggested that serum enterolactone
concentration may play a role as a biomarker of a diet high in
fiber and vegetables. Owing to its phenolic structure, enterolactone
and its plant lignan precursors, which are converted by intestinal
bacteria to enterolactone, are potential antioxidants. METHODS:
The associations between serum enterolactone . . .
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Serum enterolactone and risk of breast cancer: a case-control
study in eastern Finland.
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View Article on Pub Med Web site
Pietinen P, Stumpf K, Mannisto S, Kataja
V, Uusitupa M, Adlercreutz H.
Department of Nutrition, National
Public Health Institute, Mannerheimintie 166, 00300 Helsinki,
Finland. pirjo.pietinen@ktl.fi
Phytoestrogens have been linked to
a risk of breast cancer. The main phytoestrogens in the Finnish
diet are lignans, and enterolactone is quantitatively the most
important circulating lignan. The purpose of this study was to
examine the association between serum enterolactone and risk
of breast cancer in Finnish women. The subjects were participants
of the Kuopio Breast Cancer Study. . .
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