In addition to its phytoestrogen like activity, HMRlignan™ is a powerful antioxidant and free radical scavenger.

In vitro tests show HMRlignan™ to be a strong antioxidant more or equipotent than the standard reference compound, Trolox. HMRlignan™ has also been shown to incorporate into isolated LDL fractions, and to protect from copper-induced LDL oxidation in vitro. An exceptional feature of HMRlignan™ is the capability of the molecule to scavenge up to 4 peroxyl radicals, one of the most common cellular damaging agents, per one molecule of HMRlignan™1. Proprietary research has discovered that enterolactone, and also to some extent HMRlignan™ inhibits the oxidative burst from activated lymphocytes suggesting that they may also modulate inflammatory reactions. Concentrations less than 1 µM of enterolactone appear to be effective in this test1.   

Antioxidant Capacity

 
Source: Eur J Cancer Prev. 2002 Aug;11 Suppl 2:S48-57. Antioxidant and antitumor effects of hydroxymatairesinol (HM-3000, HMR), a lignan isolated from the knots of spruce. Kangas L, Saarinen N, Mutanen M, Ahotupa M, Hirsinummi R, Unkila M, Perala M, Soininen P, Laatikainen R, Korte H, Santti R. Hormos Nutraceutical Ltd, Turku, Finland.