A significant body of research has found benefits of HMRLignan to include that when dietary lignan intake is increased (such as hydroxymatairesinol), as well as increased blood levels of enterolactone, is associated with improved breast health in women. The protection appears to extend all the way from adolescence to beyond menopause.4 Large population studies have found that women with the highest levels of enterolactone have a reduced risk of breast cancer compared to women with the lowest intake.
Several studies indicate an inverse relationship between elevated enterolactone levels and the risk of breast cancer. In a 2006 Swedish study, Hedelin et al. investigated the possibility of phytoestrogens protecting against cancer and the relationships between dietary phytoestrogen intake and the risk of cancer revealing that a high intake of foods rich in phytoestrogens was correlated with a decrease in the risk of cancer.